Blowing up Cancer Cells

Remarkably creative and clever approach to attacking cancer ...

In the zebra-fish study, Lapotko and his collaborators at Rice directed antibody-tagged gold nanoparticles into the implanted cancer cells. A short laser pulse overheated the surface of the nanoparticles and evaporated a very thin volume of the surrounding medium to create small vapor bubbles that expanded and collapsed within nanoseconds; this left cells undamaged but generated a strong optical scattering signal that was bright enough to detect a single cancer cell.

A second, stronger pulse generated larger nanobubbles that exploded (or, as the researchers called it, "mechanically ablated") the target cell without damaging surrounding tissue in the zebra fish. Scattering of the laser light by the second "killer" bubble confirmed the cellular destruction.

A Natural Response to Alzheimer's Disease

It was only a few years ago that most believed amyloid plaques and protein tangles could not be removed from the nervous system. We now know better and recent findings have important implications for our cerebral health. Over recent years there have been a number of studies highlighting that in contradiction to another once well established opinion, age associated cognitive impairment is not inevitable and there exist a wide range of strategies to ameliorate cognitive decline with aging. Achieving that goal, and in these days that is a realistic goal, is no easy task. It requires a variety of strategies but the long term pay offs are potentially enormous. This possibility first occurred to me on yet another afternoon when I had the energy of a bamboo deprived panda, I was flicking through TV stations and caught a glimpse of an interview with BF Skinner. He related that at his age, 85, he felt he was still going work but he stressed that throughout his life he had been very careful about his health. There is a very important for those who wish to live long and prosper: if that truly is your goal you had better start living towards that goal before you are 35 years old.

Patrick Lockerby: Arctic Ice Update

Every month or so Patrick provides update on the ice dynamics in the Arctic. Here is the latest report. Thanks Patrick!

Daleks Thwarted by a Call Centre

Funny.

Epigenetics and PTSD

This news release from Science Daily highlights yet another epigenetic study that raises difficult questions about our understanding of natural selection. There is a long, fascinating, and in some ways sad history about epigenetics. It all began with the Australian immunologist Ted Steele.

Does the Impact of Psychological Trauma Cross Generations?

It has been assumed that these trans-generational effects reflected the impact of PTSD upon the parent-child relationship rather than a trait passed biologically from parent to child. 

However, Dr. Isabelle Mansuy and colleagues provide new evidence in the current issue of Biological Psychiatry that some aspects of the impact of trauma cross generations and are associated with epigenetic changes, i.e., the regulation of the pattern of gene expression, without changing the DNA sequence

The Australian immunologist Ted Steele, in the 1970's, was the first to strongly argue for a Lamarckian style of inheritance. I read his book long ago, Lamarck's Signature, and put a question mark over it, waiting for studies. Ted Steele was treated like a pariah by the scientific community. Not surprising, science does have its stories of the intellectually adventurous being burnt alive. A friend of mine once noted that Aussies tend towards the iconoclastic type. (Can we find an epigenetic trait for that Frank!?). Ted Steele, and that wonderfully cynical and insightful Aus philosopher, Dave Stove, are excellent examples of that iconoclastic motif. Dave Stove is one of those few precious philosophers who can call out bullshit with remarkable clarity. For example, in regard to the Selfish Gene hypothesis, one of the dumbest ways you can ever perceive genetics, Stove writes: if genes were that selfish incest would be all the rage. So FU Dawkins, I always knew you were wrong and now everyone does. But I digress ...

Epigenetics Nutshell: The concept refers to changes in gene transcription mediated by the the attachment of methyl and\or acetyl groups to the proteins which surrounds genes (chromatin, heterochromatin) and impact on the rate of gene transcription.

Ted Steele's fight cost him his career, he was even subject to disciplinary proceedings which were later thrown out on appeal. In science rocking the boat can have you tossed overboard. He crossed a sacred barrier, the Weismann Barrier. This refers to the long held view that irrespective of what happens to the body(soma), the germ line cells remain unaffected. We can now regard that as unmitigated bollocks.

There are deep and difficult questions surrounding epigenetics. This study highlights one such problem. For it is unimaginable how epigenetic changes could have the precision suggested in this article. The same problem is suggested in relation to epigenetic findings on diabetes, that if your grandparents went through a noticeable famine your diabetes risk was raised. This is quite fascinating, especially when you consider that India is the diabetes capital of the world and aborigines also have extraordinarily high rates of diabetes. How's that for an unintended consequence of being well fed! So even if we looked for gene changes the answer may be masked, what we need to also look for is epigenetic changes. These findings and many like findings have profound implications for our understanding of evolution. It is going to be another revolution and calls into question all those models of gene variation and natural selection dynamics.

BTW, a study released a few months ago suggested that congenital mental retardation can occur not through changes in the genes but in epigenetic changes.

Follow Patrick Lockerby on Scientific Blogging

Hats off to Richard Lockerby for his continued efforts to bring the science of climate change to the wider public. His recent post, Mad 2.0, illustrates the urgent need for the wider public to become much more informed about the science of climate change. Follow his posts because Patrick has an excellent grasp of the problem and the need for urgent change.

Behaviorism and Culture

A friend of mine in the USA sent me this long (30min) and fascinating video which highlights the development of a new perspective on cultural analysis that is based on ideas drawn from behavioral analysis. This is a seminal approach and will take many years if not decades to be explored. There are some interesting ideas being explored here, the talk introduces these ideas but you'll need to track down the relevant research to obtain a larger picture. Great stuff, pleasing to see that there is at least someone out there trying to develop a novel approach to understanding cultural dynamics.

Monkey Economics

Primate Economics

Longevity(Exceptional) - the genes have it

This recent press release has caused a world wide stir, with critics pointing out flaws in the analyses, though with the caveat that the identified flaws did not disprove the conclusions but raised questions that needed further investigation. In that link the researcher states his own research also identifies 150 specific markers in the exceptionally long lived. This more critical analysis though suggests the whole methodological approach is up the creek with one scientist quoted as saying the paper should not have been published because all the conclusions are suspect. The question is: Do we now know enough to enable people to realistically aim at extending their healthy lifespan? Not with studies like the above, but when the current centenarians were born people were only just becoming interested in the work of the quiet monk, Gregor Mendel, who pioneered modern genetics. Today we know so much more, and there is sufficient information to suggest it is possible to increase our lifespan and avoid illness. It is still a numbers game but we can play with the odds. First, some more of these genetic studies ... .

Diabetes Mediated by Pollution

This news release reminded me of this prior research which prompted me to think about this research. Then I found this and  this and this and this  and this which of course led to the obvious hypothesis being thus  and thus (full text available at link)all of which reminded of this recent research news wherein they still fail to recognise the obvious hypothesis. Take note from the last reference:

One striking observation is that obese persons that do not have elevated POPs are not at elevated risk of diabetes, suggesting that the POPs rather than the obesity per se is responsible for the association.

At a personal level I find this quite incredible because several years ago I wrote up a report for an environmental group wherein I argued that the compounds found in many electronic components were known to be toxic and needed to be safely disposed of instead of being put in landfill. The Queensland Environmental Protection Agency laughed at my report. Idiots, it was the obvious hypothesis back then, if only because several countries had already passed legislation to address the issue.

All that is a friggin disaster.