One of the more remarkable features about depression is the number of therapies that have proved beneficial. I explored that issue in this post. This latest study highlights the importance of prostaglandin regulation in depression. This latest study, the largest ever trial on omega 3 fats in treating depression, demonstrates a careful delineation that helps clarify the role of omega 3's in treating depression. The nutshell is this: they focused on EPA, typically at 120mg in your fish oil tablets, and boosted that intake to a big 1000mg per day. That's a lot but given the role of EPA in regulating prostaglandin pathways makes good sense.