Antidepressants for Hot Flashes?- Looking for Alternatives to HRT?

Menopause and post-menopause is a rough time. Most doctors recommend hormone replacement therapy (HRT) to help alleviate the symptoms of menopause. While it is effective, there are many different side effects and issues that come up with hormone replacement therapies that make them undesirable for so many people. Hot flashes and other symptoms are difficult to deal with and finding the best treatment is difficult for some women. At our age, we deserve to enjoy life. I've tried HRT and quite frankly, I didn't like the effects that it gave me. I chose to stop taking the treatments and found natural solutions to deal with my issues.

According to a new study, the antidepressant desvenlafaxine was shown to help control hot flashes in the women involved in the study. A lot of women can't take estrogen and other hormone treatments. Some simply don't like the way that the HRT works. In either situation, having a better alternative is going to help a lot of people. Within 12 weeks, many women saw a 62% reduction in their hot flashes and other symptoms after taking the anti-depressant. While it is effective to take hormone therapies, some women prefer the use of this medication because it offers better solutions with fewer adverse effects.

HRT is also not an option for women who have or have a risk of breast cancer, which is what sparked the search for better alternatives for menopause relief. As it turns out, many different forms of antidepressants can actually help alleviate the hot flashes for women who need an alternative to traditional treatments. These medications are often used for health issues outside of depression, so this news isn't exactly surprising to many people. However, the use of antidepressants to treat menopausal symptoms is definitely going to help many women who are looking for something different.

Studies are still ongoing and in time things will likely get better in time, but for now this health science advance is enough for some people.

Mary Albert is a health advocate and blogger for Lifestyle Health Guide, where she contributes regularly on topics like senior aging, health news, and medical alerts.

Sodium Reductions Might Not Affect Heart Health

According to an article written in Time magazine, they've been doing research in Europe that proves that lower sodium intake might not actually help heart health in the long run. Studies have shown that people who have high blood pressure or heart disease would benefit from lowering salt intake. However, in a study of more than 3,500 people who didn't have heart problems, the ones who had the highest salt intake were the lowest risk for heart disease-related death. The study was done for more than eight years and those with the highest sodium levels only had a 0.8% death rate. Those with low sodium had a 4% death rate.

All the unique things that the health science world is doing today never cease to amaze me. It's like the blog that I wrote awhile back on senior safety and wellness, which talked about how education is so very important to your health. COPD symptoms can be reduced with exercise, Alzheimer's can be staved off with walking, and now apparently sodium isn't going to be terribly bad for your heart. But why is this?

According to researchers, while salt intake does affect blood pressure, it doesn't increase the risk of hypertension or a death related to heart disease. It apparently doesn't have as much of an effect as they thought, and is much less of an issue. The American Heart Association is still hard at work trying to convince people to lower their sodium intake just for the sake of their health, but there's apparently less of a connection to heart health than was previously thought.

The study does have its flaws, of course. The volunteers were all younger, so the follow-up might not have been effective enough due to the age at which these heart issues usually occur. Either way, it is a complicated issue that people have to face and learn about for themselves. Nothing is more important than being educated and you really need to read up. Medical science never ceases to impress me with its findings, but this just goes to show that you have to get the details before you tip the salt shaker.

Mary Albert is a health advocate at Lifestyle Health Guide, where she contributes regularly on health issues and medical alert systems.

Educate Yourself on Alzheimer's- New Studies that Will Surprise You

In a blog I wrote a while back on healthy aging and elderly safety, I spoke about how education is such a valuable resource for people who want to maintain an active, healthy life. Being constantly in fear of your health and aging is not any way to enjoy retirement. You have to take the time to learn about your health issues, your lifestyle, and the things that will help you live the longest, healthiest life possible. In doing some research on different topics, I found a new article that was quite intriguing. While I've done research that shows that walking and exercise can help both COPD and Alzheimer's on my lifestyle and medical alert blog, this new article was quite eye-catching.

According to new studies being done, it seems that there is a gene for Alzheimer's Risk that disrupts the wiring of the brain as much as 50 years before the disease actually strikes. There has been knowledge of genetic involvement in Alzheimer's for a long time, but this is totally new information that has been made available. In a study done at UCLA, this new gene was tested and studied to figure out exactly what it does. Known as the CLU gene, it shows the ability to start damaging the brain as much as 50 years before the normal onset of Alzheimer's.

During the study, researchers took the time to scan the brains of those who had this gene as well as those who didn’t, and the result was that young, healthy people who carried this gene were already showing a decrease in the integrity of white matter in the brain. That means that they're already showing effects that are putting their brains at risk for developing full-blown Alzheimer's in the future. This is remarkable, but also scary for many people.

Fortunately, as research continues to become available and give people the resources that they need, it will hopefully be easier to pinpoint the effects of genes and find a way to stop them from leading to this terrible condition. My mother suffered from Alzheimer's and I personally don't want to face it for myself after seeing what she went through. This study proved that 88% of the Caucasian population has this gene and while all of them don't end up getting Alzheimer's, it does put them all at risk for developing the condition. Hopefully they will continue to develop this research and find a way to put it to good use.

Mary Albert is a health and lifestyle blogger at Lifestyle Health guide. She commonly writes about aging and health issues as well as medical alert systems.

Medical Advances- Understanding Technology and Health News

I was recently reviewing a blog I wrote awhile back about the benefits of medical alarm systems, and really wanted to reach out and talk about medical and health technology and advances that can be used to our advantage. As retirement approaches, or as it carries on for some of us, knowing the different advances in technology that are available is often helpful. Medical technology like medical alert systems is constantly growing and changing, and it doesn't always have to be high-tech to be successful.

The medical alert system has remained largely unchanged since it was first debuted decades ago, and its simplicity is often what makes it such a popular item. There are a lot of highly technical products and services on the market today, but they only offer benefits when their technology is suited to the audience accordingly. I'm not incompetent, but I also don't have months to spend learning about all these new gadgets and gizmos that are supposed to make life 'better'. Heck, it took my kids quite a few years to convince me to set up one of those Facebook pages, and I barely understood that.

Being educated about health technology is important, no matter how simple it might be. These advances and new innovations are designed to make our lives better and more enjoyable, which is why staying on top of things will always be beneficial. There's a lot going on in the medical industry right now and technology is creating changes almost every single day. While this can seem difficult to keep up with, the internet makes it easy. Find the best resources for health news and technology updates so that you can be an informed consumer.

Education is the key to getting rid of your fears or confusion about anything. If you want to have a happy, healthy retirement that you can enjoy, you need to understand how technology is working to benefit you and what types of advances are being made in healthcare and other areas that will positively benefit your life. Being a health advocate, it's easy for me to stay educated and share that education with others. Thanks to the internet, however, anyone can learn about advances in technology, including medical alert systems and other health and wellness solutions.

Mary Albert is a health writer for Lifestyle Health Guide, and a professional health advocate.

Patrick Lockberby - The Artice Decade - March 2011

Great piece of work by Patrick. 

Patrick Lockberby - Artice Ice Update - March 2011

Hmmm, this is not good:

"Arctic sea ice extent for February 2011 tied with February 2005 as the lowest recorded in the satellite record." 

Interestingly, 2005 was a year of very high sunspot activity and this year sunspot activity is also high.

Apocalypse 2012: An Investigation into Civilisation's End

Book Review: Apocalypse 2012: An Investigation into Civilisation's End.
Lawrence E. Joseph.
Broadway Books, New York, 2007

I find this a perplexing text. So many new ideas from so many different sources. The author traveled around the world to interview scientists, psychics, Mayan ancestors, and various individuals ranging from shamans to mystics. It would take me far too long to investigate all the claims in this text. Other reviews on this text indicated a mixture of respect and caution in judging this text. There are errors, there must be errors, but there is enough solid material in this text to leave me interested.

The first two thirds of the text are an entertaining read. The author employs an easy reading style that doesn't become too technical and bogged down. Thankfully the text is not alarmist or written as if being some great document of revelation. He quotes the relevant individuals, he puts forward their ideas clearly and without editorialising their statements.

A Counter Intuitive Study on Longevity

There is no easy way to establish strategies for living a long life. This news release adds to our confusion. I proffer the following cautions:

1. This study contradicts many other studies. When that occurs don't accept the study at face value, it needs to be subject to critical review by many people, and believe me that is far superior to peer review! 
2. This study is relying on data gathered a very long time ago, when experimental methods were much less refined than today. 
3. It relates to analysis of "more than 1500 bright children". Small sample, and just what do they mean by "bright". 

The new release does not point to a published paper, the results are being published in book form. I would much prefer that they first publish a series of papers then publish their book. By publishing the book first they are putting out a view on longevity that has not been subject to (1) above.

For myself at least I have to disregard the claims of this news article. Yes I can see elements that I find plausible but in the absence of a series of papers that have been subject to critical review and discussion by a wide range of people it is virtually impossible to know if all their conclusions are valid.

There is a good lesson here in relation to health news. There are also sorts of claims being made about the secrets to longevity. There are no secrets, we're still learning, but obviously a good deal of common sense goes a very long way. Eat well, exercise regularly, and don't go looking for fountains of longevity.

The Brain's "Reward" Centre Also Responds to Fear

One of my pet hates in neuroscience is the propensity to attribute highly specialised functions to currently identified brain regions. If only it were that simple. This study, remarkable in its detailed analysis, again reminds us that the brain is not only a wonderful thing but an incredibly wonderfully complex thing.

It has long been known and studied that the ventral tegmental area(VTA), a rather small nucleus in the midbrain, is very much involved in "reward" processes. Illicit drug use very often involves the VTA dopamine neurons becoming rather active. Even marijuana, who some claim is not addictive, will involve activation of these neurons.  Note though that the abstract refers to a specific location in the VTA - the posterior region. These nuances in how these "cerebral modules" respond needs to be kept in mind. For example, we often read that the amygdala is a "fear center". For example, consider this recent news release which appears counter intuitive. In that news release, the so-called "fear centre" - amygdala appears to play a role in reducing anxiety. Note though that is very misleading to refer to a "fear centre". Neurons don't experience fear, we do! As the linked Wiki article states, the amygdala can be subdivided into many regions. For an excellent introduction to the amygdala, try reading "The Emotional Brain" by Joseph LeDoux, who pioneered important research into this region.

This study identified 3 types of dopamine neurons in the VTA. While Type 1 and Type 2 neurons did not respond to fearful events, actually decreasing their firing rates but with a rebound at the cessation of the fearful event, Type 3 neurons increased their firing rate. Thus ...

Moreover, the excitation duration of type-3 dopaminergic-like neurons also correlated with the duration of fearful events.

However I am puzzled by this and have to wonder if it points to error in identifying these Type 3 neurons:

Our pharmacological results revealed that the vast majority (96%; 23/24) of type-1 and type-2 putative dopamine neurons were significantly suppressed, while surprisingly the type-3 neurons (n = 9) otherwise showed excitation by apomorphine

The bods then went onto to test how these neurons responded to both positive and aversive events:

Neuronal activity recordings in these conditioned mice (after 1-week training) revealed that VTA putative dopamine neurons responded significantly to the conditioned tone that predicted a sugar pellet in the reward chamber (Figure 6D, left panel). Interestingly, the same VTA neurons also responded reliably to the same conditioned tone when it predicted free fall in the free fall chamber (Figure 6D, middle panel). When the same conditioned tone was delivered to mice in a neutral chamber that was not associated with any event, it did not produce significant changes in firing.

What this suggests is that these neurons in the VTA are not only responding to reward or adversity but also to the expectation that something in the environment is about to change. It would be interesting to see if any of these neurons would respond to innocuous environmental contingencies. I have a sneaking impression that what we are witnessing here is a general alerting function to a change in the environment, with different neurons providing information about the nature of the environmental change. This information is highlighted by a sentence in the closing paragraph of the paper:

These putative dopamine neurons respond to different negative events in a similar manner and more importantly, their temporal durations of dynamic firing changes are proportional to the durations of the fearful events.

Our Vagabond Minds

Be warned, I'm calling shenanigans on this one.

ScienceDaily (Nov. 11, 2010) — People spend 46.9 percent of their waking hours thinking about something other than what they're doing, and this mind-wandering typically makes them unhappy. So says a study that used an iPhone web app to gather 250,000 data points on subjects' thoughts, feelings, and actions as they went about their lives.