Can Diet Reverse Alzheimers?

Hope springs eternal, except when you're dead. (With no Arrow of Time is one eternally dead or eternally alive? Or am I in a box and if God happens to look inside will my fate then be decided? God, don't look!) On the internet there is a cure and conspiracy for everything. Such is the nature of human cognition, a ramshackle attack on reality that through brute force manages to get enough things right amidst the a multitude of errors and disasters. I read Camus in another life and I really must try to start forgetting him.

If the only significant history of human thought were to be written, it would have to be the history of its successive regrets and its impotences.

The Myth of Sisyphus, page 24

I seriously doubt there can ever be a cure of Alzheimers. (At the end of this post though I do suggest one idea that is worthy of serious consideration.) By the time diagnosis is made the damage tends to be extensive. Take Parkinsons Disease as an example, the individual can lose up to 60% of the neurons in the substantia nigra before symptoms arise. In dementias generally, by time of diagnosis a vicious physiological cycle of destruction has become established and at present there is no obvious solution to that problem. There is an increasingly detailed understanding of these processes and in time it will be possible for individuals to institute strategies that can seriously arrest the progression of even advanced dementia; though at that stage of dementia I'd rather take a bullet than pills. Such treatment expectations however are for another generation.

In our time, studies like this point to strategies that *may* help us. All things considered, it will not be a matter of single strategies or golden elixirs, but rather a lifestyle that incorporates a variety of strategies to minimise the risk of dementia.

SAM-e can be Dangerous

SAM-e is being widely promoted as a "natural antidepressant". Quite by accident I recently stumbled upon some data which indicated that sustained use of SAM-e is potentially very dangerous.

SAM-e is S-adenosylmethionine. Part of its known actions is to act as a methyl donor. If you are using SAM-e you must make sure your vitamin B levels are adequate. The use of SAM-e has been associated with hyperhomocysteinemia, excess SAM-e is associated with Parkinson's Disease like disorders, excess methyl donation is a risk factor for some cancers, and the hyperhomocysteinemia that can arise from unwise use of SAM-e can induce atherosclerosis. It has also been found that in the brains of schizophrenic patients there is an over expression of SAM-e. Excessive SAM-e also induces oxidative stress and lipid peroxidation.

If you are taking S-adenosylmethionine be absolutely certain you have a very good intake of the B vitamin group, particularly folate, and you have a good antioxidant intake as well.

NEVER take SAM-e in conjunction with any antidepressants, "natural" or otherwise. It is probably advisable that before taking SAM-e you should have your homocysteine levels checked. If these levels are high then do not take it and immediately boost your intake of B vitamins and folate.

If you are using SAM-e for depression you might want to consider an "unnatural antidepressant" prescribed by your doctor. Antidepressant drugs are amongst the most widely prescribed drugs and have been subject to extensive trials and analysis. They have an excellent safety profile but it can take quite some experimentation to find the antidepressant that works for you. As recent studies have indicated the efficacy of antidepressants appears contingent on the induction of neurogenesis. This is probably a downstream effect from antidepressant use. At present I am taking an antidepressant. No, I'm not depressed, I just prefer the occasional dosing of an antidepressant because the one I am using has a number of favourable qualities.

Ideally if you are suffering from depression you should first try strategies that do not require taking anything. Check your diet, get some regular exercise, spend time with positive people, stabilise your sleep patterns if need be, get out in the sun occasionally(yes, sunshine, probably via circadian regulation and vitamin D, can give a slight boost to serotonin levels), and find ways to reduce your stress levels.

A brief overview of SAM-e is available at Wikipedia.